As growing up I always wanted to get away from the city areas and live in some place which is quiet and less clustered. As kids have different imaginations like some wanted to live in a jungle and some of them wanted to live in a magical place far away. but as a kid I always wanted to live in a magical place far away. but as a kid I always wanted to live in a tree house.

In the embracement of trees and chirping birds. I wanted to build a tree house with a lot of books. when we move ahead in the world everything has its own advantages and disadvantages. some of the disadvantages of living in a tree house are as follows.

mostly people who wanted to live in an isolation always wanted to go and live in a tree. so one might feel loneliness there would be network issue he/she won’t be able to get news from the outside world.

It is a tree house so there will be issues with the bugs and spiders.

Several trees go up in flames. it could be a disadvantage for eg: amazon fire

now, lets move on to the advantages:

first of all, we would be able to connect with nature.

nowadays people are always on phone so this could be an escape route and be one with nature.

Tree houses can be build at a cheap prices and it can be made moveable and customizable.

From time to time, many great saints were born in India. One of them is Sant/Saint Ravidas, also called Raidas, (flourished 15th or 16th Century), a spiritual poet and a great saint and popularly known as Sant Ravidas. Sant Ravidas ji was one of the most renowned saints of the Indian Bhakti movement.
It is believed that Guru Ravidas Ji was born on the Magh Purnima day on Sunday in the year 1433 in Kashi present Varanasi in a so-called ‘untouchable leather-working caste’, but his knowledge, wisdom, spiritual development, and humanitarian activities were at the zenith which cannot be compared with many other-caste persons. Undoubtedly, Sant was endowed with the pure and holy soul as he had proved by caste one cannot be great.
Many researchers believe that Sant met Guru Nanak Dev Ji, the founder of Sikhism, and altogether 41 of Guru Ravidas Ji’s poems were included in the Adi Granth.
Sant Ravidas ji was a prominent figure in the bhakti movement and a renowned poet of the Nirgun Bhakti tradition that valued the worship of a formless God. In this context, two foreign researchers who have carried out an extensive study on Sant Ravidas Ji’s activities may be mentioned. One is Dr. Winand Callewaert and another one is Dr. Peter Friedlander as both have published many books and articles on Sant. They have translated his songs also. One is presenting here. It may be mentioned that Prof Dr. Winand Callewaert was a scholar in Sanskrit (studied in India) and taught this subject in foreign countries. He has published many books and articles in English, Dutch and Hindi. Another scholar Dr. Peter Friedlander lived in India from 1977-1982 and learned Hindi in Varanasi. He then studied at SOAS London University and completed his Ph.D. on the life and works of Saint Ravidas in 1991. The following is a popular verse from Saint Ravidas, translated by Dr. Winand Callewaert and Dr. Peter Friedlander,
“Raidas says, what shall I sing?
Singing, singing I am defeated.
How long shall I consider and proclaim:
absorb the self into the Self?
This experience is such,
that it defies all description.
I have met the Lord,
Who can cause me harm?
Hari in everything, everything in Hari –
For him who knows Hari and the sense of self,
no other testimony is needed:
the knower is absorbed”.
(Hari here refers to God who takes away all the sorrows of his devotees).
Sant Ravidas Ji was against the caste system and in his poetry, questioned caste hegemony, valued labour of all sorts, as well as a life of simplicity and morality. He initiated dialogues with then upper-caste Hindus about caste, social justice, love, and forms of worship. He spread the message that “God created man and not man created God”, which means everyone is created by God and has equal rights on this earth. This theory in the present days no one can deny as all human beings have equal rights. It is believed that because of his wisdom, in-depth spiritual knowledge, and discourse many persons of all castes including the King and Queen of Chittoor presently in Rajasthan were his followers.
In Sant Ravidas Ji’s name, a temple has been constructed in his hometown, where Sant is worshipped every day. His songs are recited every morning and evening in the temple. His birthday is celebrated every year on Magh Purnima day. This year it has fallen on 16 February 2022.
Although Guru Ravidas Ji has passed away long ago he will be in the hearts of millions for his spiritual, devotional, and humanitarian activities generations after generations. I offer my respectful Pronam to the Great Soul, Saint, and Guru on his birth anniversary.

What are vaccines?

Vaccines are classified into several categories, however they all act on the same premise. This is done to prime the immune system to recognise a pathogen (a disease-causing organism) or a component of a pathogen. If the immune system is educated to recognise this, the pathogen will be expelled from the body if it is subsequently exposed to it. The immune system recognises foreign ‘antigens,’ which are pathogen elements on the surface or inside the pathogen that are not ordinarily found in the body. To create protection, the earliest human vaccines against viruses used weakened or attenuated viruses. Cowpox was included in the smallpox vaccine because it was similar enough to smallpox to protect against it but did not generally cause major sickness. Rabies was the first virus to be attenuated in a lab and used to develop a vaccine for people.

Types of vaccines

Whole virus vaccines

1) Viral Vectored Vaccines

Unlike most traditional vaccinations, viral vector-based vaccines do not include antigens but instead employ the body’s own cells to manufacture them. They accomplish this by delivering genetic code for antigen, in this case COVID-19 spike proteins present on the virus’s surface, into human cells via a modified virus (the vector). The vaccine simulates what happens during natural infection with some pathogens, particularly viruses, by infecting cells and commanding them to produce huge amounts of antigen, which then triggers an immune response. This has the benefit of inducing a significant cellular immunological response by T cells as well as antibody production by B cells. The rVSV-ZEBOV vaccine against Ebola is an example of a viral vector vaccine.

ADVANTAGES  

• Technology that is well-established
• A powerful immunological reaction
• B and T cells are involved in the immune response.

DISADVANTAGES

• Prior exposure to the vector may limit its efficacy.
• Manufacturing is rather difficult.
• Replicating

When utilised as a vaccine delivery platform, replicating viral vectors maintain the potential to generate new viral particles in addition to delivering the vaccination antigen. As with live attenuated entire pathogen vaccinations, this has the natural benefit of providing a continuous source of vaccine antigen over a prolonged length of time compared to non-replicating vaccines, and hence is likely to induce a higher immune response. A single vaccination may be sufficient to provide protection. Replicating viral vectors are often chosen such that the viruses themselves are innocuous or attenuated, so that they cannot cause illness while infecting the host

Non-replicating

During the process of delivering the vaccination antigen to the cell, non-replicating viral vectors lose their ability to generate new viral particles. This is due to the removal of crucial viral gene that allow the virus to proliferate in the lab. This has the advantage of preventing illness and reducing unpleasant outcomes associated with viral vector proliferation. However, vaccine antigen can only be generated when the first vaccination is still present in infected cells (a few days). 

VACCINE which used viral vector technique: astra Zeneca and johnson and johnson

 2) inactivated Vaccine

The first step in creating a vaccine is to inactivate or kill the disease-carrying virus or bacteria, or one that is substantially similar to it, using chemicals, heat, or radiation. This strategy employs technology that has been shown to be effective in humans – this is how flu and polio vaccinations are produced – and vaccines can be produced on a reasonable scale. However, it takes sophisticated laboratory equipment to safely cultivate the virus or bacteria, can take a relatively lengthy time to produce, and will almost certainly require two or three doses to be delivered.

example is India’s covaxin

3) Vaccine with live attenuation

A live-attenuated vaccine employs an alive but weakened form of the virus, or one that is extremely close to it. This type of vaccination includes the (MMR) vaccine as well as the chickenpox and shingles vaccine. This method, like the inactivated vaccine, employs comparable technology and can be produced on a large scale. However, such vaccinations may not be appropriate for those with impaired immune systems.

4) Subunit vaccines

Subunit vaccines include purified fragments of a pathogen that have been particularly chosen for their capacity to activate immune cells rather than injecting the entire pathogen to elicit an immune response. Subunit vaccinations are regarded extremely safe since these pieces are incapable of producing illness.

There are various varieties: Polysaccharide vaccines comprise sequences of sugar molecules present in the cell walls of some bacteria; conjugate subunit vaccines attach a polysaccharide chain to a carrier protein to try to increase the immune response. Other subunit vaccinations are already being used widely. The hepatitis B and acellular pertussis vaccines, the pneumococcal polysaccharide vaccine, and the MenACWY vaccine (polysaccharides are examples

Vaccines based on Recombinant Proteins

Recombinant vaccines are created by employing bacterial or yeast cells to produce the vaccine. A little bit of DNA from the virus or bacteria that we wish to preserve is extracted and put into the producing cells. To manufacture the hepatitis B vaccine, for example, a portion of the hepatitis B virus’s DNA is incorporated into the DNA of yeast cells. These yeast cells may then manufacture one of the hepatitis B virus’s surface proteins, which is purified and utilised as the active element in the vaccine. These polysaccharides or proteins are known as antigens because they are recognised as ‘foreign’ by our immune system.

Even if the vaccine only contains a few of the thousands of proteins found in a bacteria, they are sufficient to elicit an immune response that can protect against the disease.

Toxoid vaccines

When some bacteria assault the body, they release toxins (poisonous proteins), and it is the toxins, not the germs, that we wish to be protected against. The immune system recognises these toxins in the same way that it recognises other antigens on the bacteria’s surface and can develop an immunological response to them. Inactivated forms of these toxins are used in several vaccinations. Toxoids are so-called because they resemble toxins but are not harmful. They elicit a powerful immunological response.

vaccines which use protein subunits are novovax

 ADVANTAGES

• Technology that is well-established
• Appropriate for persons with weakened immune system
• no living components, there is no possibility of the vaccination causing illness.
• stable

DISADVANTAGES

• Manufacturing is rather difficult.
• It is possible that adjuvants and booster injections will be necessary.
• It takes time to find the ideal antigen mix.

5) Nucleic acid vaccines

Nucleic acid vaccines employ genetic material from a pathogen, such as a virus or bacteria, to induce an immune response against it. Depending on the vaccination, the genetic material might be DNA or RNA; in all cases, it offers instructions for producing a specific pathogen protein that the immune system will recognize as alien (an antigen). When this genetic information is injected into host cells, it is read by the cell’s own protein-making machinery and utilised to produce antigens, which subsequently activate an immune response.

ADVANTAGES

• immune response involves B cells and T cells
• No live components, so no risk of the vaccine triggering disease
• Relatively easy to manufacture

DISADVANTAGES

• Some RNA vaccines require ultra-cold storage
• Never been licensed in humans
• Booster shots may be required

RNA vaccines

mRNA (messenger RNA) is used inside a lipid (fat) membrane in RNA vaccinations. This fatty coating both protects the mRNA when it initially enters the body and assists it in entering cells by bonding with the cell membrane. Once within the cell, machinery inside the cell converts the mRNA into the antigen protein. This mRNA normally lasts a few days, but enough antigen is produced during that period to induce an immunological response. The body then naturally breaks it down and eliminates it. RNA vaccines do not have the ability to combine with the human genetic code (DNA).

RNA vaccines are used in both the Pfizer BioNTech and the Moderna .

DNA vaccines

Because DNA is more stable than mRNA, it does not require the same level of protection at the start. DNA vaccines are often delivered via an electroporation approach. This method employs low-level electrical waves to allow the DNA vaccination to be absorbed by the body’s cells. Before DNA can be translated into protein antigens that elicit an immune response, it must first be translated to mRNA within the cell nucleus. There are presently no licenced DNA vaccines, although many are in the works.

start up is all depends on our choices and desires. As what we want to do and how we will reach out to our goals and this all has been in my mind everytime I thought. I use to think about it but no one actually believe it. But today you all have to believe as I have a real story of a girl who started her Start up as the way I explained to you all. But in a interesting and relatable manner. You will find it very beneficial because I also find it difficult to put the first step out. But her story make me realise that all is around us. We just have see and go with the flow destiny will take you to the roller coaster ride. Which you never imagined. It all depends on your art and work.

So she is a girl who was very shy when she a small kid. But suddenly a span of time she changed and know she is chatterbox. Her choices changes as she grow but still she don’t know exactly what she want to do. She was good in drawing. She hates maths as she score always less marks in it. She also don’t like science because of a incident happened in the school where she have to make the sprouts of the seed but she all mixed up and she could not get a single sprout but she managed to get them from her classmates. But from there she loose hopes in science.she thought to become drawing teacher as it is the simplest job but than she realised that the salary is very less and she could not manage in that. She also thought of doing journalism as her father was fond of anchor but than she realised we have to first write script. She wants to take arts as she take interest in it but unfortunately she has to take commerce she managed to pass but she want to do arts so she took an admission in ba for college and studied.

But she want to do something creative in the free time after study so she started making videos which was she performed earlier as well in school and home. And always appreciated. But it doesn’t affect her as she thought it’s normal. So as a fun and interest she just make videos and upload it. And process was repeated. Till when her one video gets viral and it spread all in the college and the family. Than she realised that her followers have increased and loved her performance. Than also she was just want to cross 10k for the button. And slowly and gradually the number increases as she started uploading on a regular bases. And one day she got an offer for show. Firstly she don’t convince but than she realised it’s real. And she move to Mumbai and do the show from their her contact increase. She got one more show. But it is not an end. The journey is much more a 20 year old girl who actually don’t think what to do she atlast thought that she will become a banker because her mom wish. But her talent reach her out in the different platforms where she never thought that she could earn as well. So never ever do what people say or the things you don’t want to do just listen to your desire and passion your destiny will take you toward your dreams. To start something is very difficulty but when you achieve something out of it you will realise it’s worth.

Intra-family marriages are the leading cause of uncommon genetic diseases. Intra-family marriages are far too numerous, and first-cousin marriages have a higher risk of hereditary disorders.

When close intra-family marriages occur, more than 100 ailments are passed down down the generations. Marriages between cousins are far too common, both culturally and historically, and these disorders are passed down through the generations. Around 70% of marriages are cousin or consanguineous marriages, and hundreds of cases of genetic diseases are reported each year.

Although Islam, the state’s predominant religion, does not prevent people from marrying outside of their family or caste, many families prefer to marry within their own families due to illiteracy and caste difficulties. Because of their ignorant brains, dangerous infections are permitted to spread to newborns, which is considered criminal neglect.

Doctors recommend that every couple have a genetic test before getting married because deficits are stored in particular compartments of body cells. The material that builds up in each lysosome expands and takes up a lot of room in the cell, causing a slew of other issues with cellular function, which is how illnesses spread.

 

According to experts, if these disorders are handed down to a child, the child would develop abnormalities. This can include mental abnormalities or organ enlargement, both of which might cause a kid to die from a serious health issue.

More than 70% of all marriages are between members of the same family. This custom is observed as if it were a religious obligation, but it is not. The predominance of Thalassemia, a blood condition, in the country is a major result of this custom. Blood transfusions and iron chelation are two options for treatment.

In a recent interview, a doctor stated that if one parent contains a gene for an illness, the condition does not transmit to the child.

However, if both parents have the same condition, which is common in intra-family marriages, the defective genes are likely to be handed down to the child.

More than 50 children have perished in recent years as a result of genetic abnormalities that have arisen from first-cousin marriages. Three brothers were admitted to a hospital last year for treatment of a handicap. It was discovered that their family members were quite superstitious and did not approve of outside-the-family weddings. The three boys were born healthy but developed a handicap later in life.

Government funds should be set aside to study genetic problems caused by intra-family marriages.

Doctors believe that more people should be informed of the consequences of marriages within families. First-cousin weddings should be prohibited since they cause a slew of ailments that are destructive to the next generation’s future. The government is being urged to take action on this critical subject, and everyone should be able to pick their life partners outside of the family.

“As children, our cousins are frequently our first friends. Even if you haven’t spoken in a long time, no one will ever understand your eccentric family like your cousins.”

Artificial Intelligence, or AI, is used in our daily lives for things like navigation and automatically setting your alarm clock on workdays. Artificial intelligence is one of the most rapidly developing disciplines of technology worldwide. AI is a type of technology that combines computer intelligence with the ability to think like a human to analyse data and make predictions, recommendations, and judgments. It’s a collection of technologies, algorithms, and methods. Since 2016, AI has seen a significant shift in public attitude, with people becoming more accepting of the technology.

Artificial intelligence (AI) is exploding all over the world, particularly in Japan. With AI as one of its key components, Japan has achieved a major place in the high-tech sector. Japan intends to create the society of the future by devising a long-term strategy based on the new prospects that high-tech breakthroughs present. Artificial intelligence (AI) is a vital technology that allows for the processing of large volumes of data and the smooth translation of that data back to human users.

The Artificial Intelligence Industry in Japan
For the longest time, AI in Japan has mostly concentrated on robots as sub-domains of artificial intelligence, with AI being developed in particular in the fields of technology and medical.

According to the Nomura Research Institute, Artificial Intelligence in Japan is on the verge of exploding, with AI robots performing half of all professions in Japan by 2035. While the Japanese AI market has been focusing on robotics, other companies across the world have been focusing on software development, which is an area of opportunity for foreign companies trying to enter the Japanese AI market.

Japan’s AI Ecosystem

In Japan’s AI field, there isn’t just one sort of area that is the most important or dominant, but rather a collaboration of areas such as public, private, and research domains that are all interconnected.

The private sector, the public sector, and research facilities are the three types of areas. These three categories are interconnected, and the division between them is constructed in a highly schematic manner. As a result, the categorization into three sorts of zones is merely a simplification of the reality.

Japan’s cutting-edge AI firms
When it comes to the AI market in Japan, there are around 300 businesses. Large competitive organisations, small to mid-sized businesses, and start-ups are among them. The following are some of the significant businesses:

NEC
NEC, based in Tokyo, is a global leader in the integration of IT and network technologies, with a long history of AI research dating back to the 1980s.

NEC delivers sensors, computation, networking, and analysis to help society with technology solutions. Their active data solutions are capable of anticipating, monitoring, and resolving problems, as well as intelligently responding to bad situations.

Abeja

This Japanese company is a start-up that uses artificial intelligence. It was launched in Tokyo in 2012, and it has since assisted over 150 organisations in implementing AI in a variety of industries, including manufacturing, infrastructure, logistics, and retail. Machine learning and deep learning, as well as retail shop analysis, are their key areas of focus.

Tokyo, Paris, London, San Francisco, Boston, Shanghai, Beijing, Shenzhen, Hong Kong, Singapore, Seoul, and Sydney are among its offices. SoftBank Robotics currently has over 35,000 robots in use in over 70 countries, with new applications in retail, tourism, healthcare, finance, education, facilities management, and cleaning.

Japan has devised a strategy for creating a future civilization that incorporates AI into practically every area of daily life. The reason for its rapid growth is that Japan’s home welcoming environment for new AI approaches is founded on collaboration between the Japanese government, the business sector, and, of course, their know-how.As a result, AI will be critical in transforming the information society into the society of the future, also known in Japan as Society 5.0, which is defined as “a human-centered society that balances economic advancement with the resolution of social problems through a system that highly integrates cyberspace and physical space.”

“It was my father who instilled in me a sense of self-worth.” Dawn French –

A father is the child’s male parent. Fathers may have a parental, legal, and social relationship with their children, which comes with its own set of benefits and duties.

 

An improved father-child relationship may contribute to a child’s social security, academic performance, and other factors. Their children may also have better problem-solving abilities. Children who are typically raised by fathers perceive themselves to be more cognitively and physically acceptable than their classmates who are not reared by fathers. Mothers who raised their children with a father had fewer disputes with their children.

 

Internal events and behaviours can influence fatherhood as a legal identity.

“Anyone may be a parent, but only a special person can be a father, which is why I refer to you as dad since you are so important to me. You showed me how to play the game and how to play it correctly.” Wade Boggs (Wade Boggs)

Even if your father says he doesn’t want any gifts, you know it’s impossible for you to not give him something on such a wonderful occasion. After all, he’s the guy you’ve looked up to your entire life, so it’s only right to purchase him a Father’s Day present that reflects how much you appreciate everything he does for you. It’s challenging to choose the perfect present for your father.

So, here’s a list of present suggestions:

-Fragrances and perfumes
-Cakes and Chocolates
-Wallets, Belts, and Sunglasses 
-Shirts and T-shirts 
-Books 
-Cufflinks 
-Customized Mugs
-Diary -Grooming kit

Fathers’ Role

 

As previously stated, anyone can father a child, but it takes a lifetime to be a father. Fathers can play a unique role in the lives of their children that no one else can. This job can have a significant impact on a child’s development and help form him or her into the person they become.

Fathers, like mothers, can make a significant difference in a child’s mental well-being. Children look up to their fathers for a sense of security, both physically and emotionally. Children want to be proud of their parents.

When fathers are extremely loving and helpful, their children’s cognitive and communicative development is greatly enhanced. It also gives you a general feeling of well-being and self-assurance.

Fathers shape not only who we are on the inside, but also how we interact with others as we grow up. What a father looks for in other people is determined by how he approaches his child. The patterns that a father establishes in his interactions with his children will influence how his children interact with others.

For security and emotional aid, girls rely on their fathers. A father demonstrates to his daughter what it’s like to have a terrific connection with a man.