Tag: disease

HISTOPLASMOSIS-SYMPTOMS,TREATMENT, DIAGNOSIS

BY DAKSHITA NAITHANI

INTRODUCTION

Histoplasmosis is a fungal infection caused by Histoplasma capsulatum, a fungus. Spores suspended in the air by birds and bats are frequently the source of this illness. If the infection is limited to the lungs, it is not dangerous. It might be deadly if it spreads across the entire body. This condition mostly affects immune-compromised people, most of who are suffering from AIDS.

Histoplasma capsulatum is a soil microorganism that is frequently linked with decomposing sediments. Infectious elements are frequently released by disrupted soil particles, which are breathed by humans and settle into their lungs.

Histoplasmosis is often known as the Darlings’ disease, after Samuel Darling, who first found the virus in Panama.

SYMPTOMS

Histoplasmosis is characterised by a high fever. The fungus Histoplasma causes no symptoms in the majority of persons who are exposed to it. Others may experience symptoms that subside on their own.   Coughing: Fatigue (severe exhaustion): Chills: Headache: Body aches: Chest pain Histoplasmosis symptoms might emerge anywhere from 3-17 days after a person inhales the fungus spores. These symptoms usually fade away in a few weeks to a month for most people. However, some people’s symptoms might persist much longer, particularly if the condition is acute. Histoplasmosis can cause a long-term infection in certain individuals, especially those with compromised immune systems, or it can move from the lungs to other regions of the body, such as the central nervous system.

RISK AND PREVENTION

If you’ve been in a region where Histoplasma is present in the environment, you can acquire Histoplasmosis. It I s frequently linked to soil disturbance, specifically soil containing bird and bat droppings. Certain persons are more likely to acquire severe types than others:

People who have weakened immune systems, for example, people who:

  • Are patients of HIV/AIDS
  • Had an organ transplant
  • Are taking medications such as corticosteroids or TNF-inhibitors
  • Infants
  • Adults aged 55 and older

Histoplasmosis cannot be transmitted from one person to another or between humans and animals through the lungs. The illness can, however, be transferred through a transplant with an affected organ in exceedingly rare circumstances.

In regions where it is prevalent, it might be difficult to avoid breathing it in. People with compromised immune systems should avoid undertaking behaviours that are known to be linked with Histoplasmosis in locations where it is present, such as:

  • Disturbing material where there are bird and bat droppings
  • Cleaning chicken coops
  • Exploring caves
  • Cleaning, remodelling, and  tearing down old buildings

Professional firms that specialise in the cleaning of hazardous material should clear up large volumes of bird and bat droppings.

TREATMENT AND DIAGONOSIS

Although direct diagnosis of Histoplasmosis (HP), one of the most common endemic mycoses in the world, is achieved by micro as well as macroscopic observation of Histoplasma capsulatum, serologic indication of this infection is important because etiologic agent isolation is time-consuming and unresponsive. To identify specific antibodies to H. capsulatum, a number of immunoassays have been utilised. Immuno-diffusion is the most often used technique for antibody detection, with a sensitivity of 70 -100 percent depending on the clinical form.

The complement fixation test, which was formerly widely employed, is less specific (60 – 90 percent). Immunoassays for detecting fungal antigens are particularly useful in patients with low immunity, with positive predicted results of 96–98%. The majority of modern diagnostic tests still use unpurified antigenic complexes derived from entire fungal cells or their culture filtrates. Clinical immunoassays employing highly pure and well-characterized antigens, including recombinant antigens, are now the focus.

For diagnosis doctors use your medical and travel history, symptoms, physical examinations, and laboratory testing. Taking a blood sample or a urine sample and submitting it to a facility is the most frequent way that healthcare practitioners test for Histoplasmosis.

Imaging studies, such as chest X-Rays or CT scans of lungs may be performed by your healthcare professional. A sample of fluid from your lungs is used or a tissue biopsy is performed, which involves taking a tiny sample of damaged tissue from your body and examining it under a microscope. Research facilities may also examine if Histoplasma may develop in bodily fluids or tissues.

 Symptoms may go away without therapy in some persons. To treat severe infection in the lungs, persistent Histoplasmosis, and infections that have moved from the lungs to other areas of the body, prescription antifungal medicine is required. Antifungal medications like Itraconazole are widely used to treat Histoplasmosis.  If you have a minor case treatment is typically not required. However, if your symptoms are severe, or if you have the chronic or disseminated type of the condition, you’ll almost certainly need antifungal medication. You may need to take medicines for three months to a year if you have a severe version of the condition.

BACTERIAL MENINGITIS

BY- DAKSHITA NAITHANI

INTRODUCTION

The inflammation of the meninges is known as meningitis. The Dura mater, arachnoid mater, and pia mater are the three membranes (meninges) that border the vertebral canal and skull, encapsulating the brain and spinal cord. Symptoms such as headaches, fever, and stiff neck are common.

Prior to the discovery of antibiotics, this was a fatal illness. Despite tremendous advancements in healthcare, the disease still has a death rate of over 25%. Many different pathogens can cause the disease, but bacterial meningitis has the largest worldwide impact.

Despite advances in diagnosis, treatment, and immunisation, 8.7 million cases of meningitis were recorded globally in 2015, with fatalities as much as 379,000. In early 2020, the first incidence of meningitis linked to COVID 19 was discovered. Every year on April 24th, World Meningitis Day is commemorated. Meningitis is one of the leading causes of illness and death in children under the age of five worldwide. According to Indian studies, meningitis is one of the main causes of mortality among infants under the age of five. 

TYPES OF MENINGITIS

Viral meningitis: It is the most frequent, but not the most dangerous, form of meningitis, accounting for 85 percent of cases. Enteroviruses are among the most prevalent causing viruses.

Bacterial meningitis: Bacterial meningitis is the second most prevalent kind of meningitis, affecting around 3 per million individuals each year. N. meningitidis, S. pneumoniae, H. influenzae, and S. aureus are the microorganisms that cause this kind of meningitis. Inflammation of the meninges can be caused by the same bacterium that causes TB.

In most countries, N.meningitidis is the primary cause of meningitis and a feared illness. The fatality rate from bacterial meningitis is frequently greater in underdeveloped nations than in industrialised countries.

Fungal meningitis: It’s a rare occurrence that generally leads to persistent meningitis. It is caused by a fungus that infects the body and travels from the blood to the nervous system, as the name implies.

Parasitic meningitis: It is less frequent than viral or bacterial meningitis and is caused mostly by parasites found in soil, excrement, cereals, or chickens. The infection is spread through ingesting the parasite’s eggs rather than normal routes. One of the most severe diseases is amoebic meningitis.

Non-infectious meningitis: It is a complication of an underlying health condition, rather than an infection. Inflammation in the tissues can be caused by a variety of factors, including drug use, head trauma, brain surgery, and cancer-related issues.

HOW DOES IT SPREAD FROM ONE INDIVIDUAL TO ANOTHER?

Meningitis caused by fungi, parasites, or non-infectious organisms is not contagious, while viral and bacterial are extremely contagious. Sneezing, coughing, and sharing utensils, cutlery, and toothbrushes are all ways to spread viral and bacterial meningitis. People who have these viruses or bacteria in their nose or throat but are not ill are generally carriers.

RISK FACTORS FOR MENINGITIS:

Risk factors for meningitis include:

•People who do not complete or skip their recommend childhood or adult immunization schedule

• Most of the viral cases occur in children younger than five years of age. Bacterial cases are common to those under the age of twenty years. Age also plays a big role in determining the risk factor.

 • It is possible to live in a community. Meningococcal meningitis is more common in college students who live in dorms and children who attend boarding schools or child care centres. This is most likely due to the bacterium’s ability to spread fast among big populations through the respiratory pathway.            

• Immune system dysfunction. Meningitis is also made more likely by AIDS, alcoholism, diabetes, immunosuppressive medications, and other immune system disorders. Anyone without a spleen should be immunised to reduce their risk.

SYMPTOMS

Meningitis affects more than two-thirds of children under the age of two, with the majority of cases occurring in the first two years of life. This might be related to low immunity and increased brain vascularity, which puts children at a higher risk. Furthermore, due to the immaturity of the central nervous system (CNS) in babies and children, the symptoms of infection are also hazy. Due to these reasons doctors depend more on the diagnostic tests rather than the symptoms.

-Fever for more than a week

-Neck stiffness

-Headaches

-Nausea and vomiting

-Altered or reduced level of consciousness

-Lethargy

-Rash

-Convulsions

Meningitis rash

A mild rash is one of the late indicators that one of the bacteria that causes meningitis, Neisseria meningitidis, is present in your circulation. The rash will become more visible as the illness progresses and spreads. The palms of the hands and the inside of the mouth, for example, may exhibit indications of a rash more easily than other parts of the body.

TREATMENT AND MANAGEMENT OF DISEASE

The therapy is determined on the underlying aetiology of meningitis. Antibiotics are used to treat bacterial meningitis, which may necessitate urgent hospitalisation. This might aid in the prevention of brain injury. The treatment of fungus meningitis may need the use of antifungal medicines. Viral meningitis may go away on its own, but you’ll need to see a doctor to figure out what’s causing it and how to treat it properly. On the basis of symptoms present parasitic meningitis is treated.

In all instances of bacterial meningitis, prompt treatment and supportive care and antibiotics are essential. Antibiotics are chosen depending on the organism that is thought to be causing the illness. In order to give the optimum antimicrobial coverage, the physician must consider the patient’s medical history.

Steroid Therapy: There isn’t enough data to back up the use of them in bacterial meningitis.

Chemoprophylaxis: Close contacts of a patient with N. meningitidis and H. influenzae type B meningitis should take this medication. People who have shared utensils, and health care providers in close proximity to secretions are all examples of close interactions.

Physical Therapy Management

In most cases, physical rehabilitation begins in the intensive care unit. It’s critical to remember a patient’s chart contraindications to therapy, such as intracranial pressure, cerebral pressure, and other lab results that dictate rehabilitation recommendations, while starting a plan of care. In the acute phase, proper posture and range of exercises should be started as soon as it is safe to do so. Proper pillow and towel placement will maintain the integrity of the skin and avoid contractures. Maintaining trunk and neck mobility is critical for functional mobility.

The earlier a patient begins therapy, the lower the risk of subsequent impairments, allowing for a better treatment.

If left untreated it can lead to significant brain problems and is sometimes deadly. In 10–20 percent of survivors, it can cause brain damage, hearing loss, or learning disabilities, as well as amputations in certain cases.

DIAGNOSTIC TESTS

 It is detected by analysing the cerebrospinal fluid, which includes a white blood cell count, glucose, protein, and, in rare circumstances, a polymerase chain reaction (PCR). A lumbar puncture is used to collect CSF, and the opening pressure can be monitored.

Bacteria in the blood are identified using blood cultures. Bacteria have the ability to move from the bloodstream to the meninges. Both sepsis and meningitis can be caused by a variety of bacteria, including N. meningitidis and S. pneumonia.

A differential complete blood count is an indicator of health general. The amount of red and white blood cells in your blood is counted. Infection is fought by white blood cells. In meningitis, the count is generally high.

Pneumonia, TB, and fungal infections can all be detected using chest X-rays. Meningitis can develop as a result of pneumonia.

A head CT scan may reveal issues such as a brain abscess. From the sinuses to the meninges, bacteria can spread.

A glass test may also be performed by doctors. The doctor performs this test by rolling a glass over the rash formed. It’s most probable meningitis rash if the rash doesn’t disappear with pressure. The odd patches on the skin may be the consequence of another ailment if it fades away.

PREVENTION

Microbes that cause meningitis can easily be dispersed all around through aerosols when a carrier coughs, sneezes or shares utensils or other oral items. A few steps which are present to prevent it are:-

• Please wash your hands. Hand cleaning is important in preventing the transmission of germs. Hands should be washed before and after meals, touching objects or animals in public places. Show children how to wash and rinse their hands completely and properly.

 •Practice good oral hygiene. Do not share edibles and utensils with anybody else.

•Maintain a good immune system by keeping a good diet and staying healthy.

 •One should always cover their mouth while coughing or sneeze.

• If you’re expecting a child, be cautious about what you eat. Reduce your risk of listeriosis by cooking meat to 165 degrees Fahrenheit, which includes hot dogs.  Choose pasteurised milk cheeses that are clearly stated on the package.

INTRODUCTION TO THE KNEE DISORDERS

When there are some imbalances within the knee then it can lead to disorders which can be indicated by deviation of the knee in terms of function. Most of these disorders occur due to some conditions imposed onto the structures present inside the knee.

BURSITIS: – inflammation (burning sensation) of the bursa causes pain.

(TIP- a word ending with itis refers to inflammation)

FAT PAD IMPINGEMENT: – the fat pad gets swollen heavily and can burst due to over-expansion.

TENDINITIS: – inflammation of a tendon

TORN MENISCUS: – a sudden twist of the knee can tear the rubbery cartilage leading to serious issues.

FRACTURE: – the bones surrounding the joint may get broken especially the patella is viable to damage in the case of accidents.

DISLOCATION: – the knee bone slips and comes out from its original location leading to excruciating pain.

ACL AND PCL INJURY: – the anterior and posterior cruciate ligament gets torn which may occur when there are a lot of instantaneous turns. However, this occurs rarely since these are very strong ligaments naturally. 

OSGOOD-SCHLATTER DISEASE: – this is the swelling of the tendon between the tibia and patellar muscles.

STRAIN AND SPRAIN: – both are injuries but strain occurs in ligaments whereas sprain occurs in tendons.

These are some of the common disorders occurring to the knee. All of these disorders have something in common….PAIN but the intensity can vary based on time and severity of the disorder

ARTHRITIS                                                      

Arthritis is a commonly used word referring to the inflammation of joints. In fact, many people have an intuition that severe pain in the knee corresponds to arthritis mainly in old age groups. This is potentially a dreadful disease and can mainly affect the old aged. Most arthritis occurs over time but some can occur suddenly. Old-aged persons are more prone to this disease. This disease is likely to affect all age groups. This disease is more prevalent in women rather than men since their joints are weaker and more susceptible to motion when compared to men.

differences between normal and arthritic knee joint

  

In the case of arthritis, the bones start to wear down, the ligaments can tear, inflammation and swelling can occur, and also lead to internal bleeding (hematoma). There are about 100+ types of arthritis with different causes and symptoms.

comparisons between some of the arthritis

The different types of arthritis have symptoms different from each other. But arthritis, in general, shows some symptoms irrespective of the type.

Joint pain, stiffness in joints, red swollen mass, deranged and irregular motion is some of the common symptoms exhibited during arthritis. These symptoms are easy to identify by a common man and hence one can consult a medical practitioner known as a rheumatologist. The study of joints is known as arthrology and it is recommended to consult such a person.

As mentioned earlier cartilage is the one that protects the bones and also acts as a shock absorber. In the case of Osteoarthritis, this cartilage starts to vanish slowly. In the case of rheumatoid arthritis, the synovial fluid gets attacked by its own antibodies!!! This phenomenon in medicine is known as autoimmune disease and occurs due to error in the programming of these cells leading to the attack on their own cells.

In the case of gouty arthritis, there is a deposition of sodium urate crystals in the joints. It can lead to redness, pain, and heat around the joint. Uric acid which is generated in our body gets converted to purines (an essential component in DNA). Increased uric acid levels can lead to its deposition in the form of crystals. The best way is to remove the synovial fluid.

So these are the different types of disorders that can be seen in the knee. Proper diet and exercise and a healthy lifestyle can prevent most of them. So it is essential to be healthy to prevent the occurrence of these diseases.

HAPPY READING!!

Vaccine

A vaccine works the immune system to recognize and combat pathogens, either viruses or bacteria. To this do the certain molecules from this pathogen must be introduced to the human body to trigger in an the immune responses. Then these are called as the antigens, they are present of all the bacteria. By the injecting these are the antigens into the body by the immune can safely can learning to the recognize them as hostile invaders, produce antibodies, remember the future. If then the bacteria of virus reappears, the immune system immediately and attack aggressively as well as the before the pathogen spread and cause sickness.

POLIO VACCINE – CDC recommends for the children gets of the four doses of polio vaccine. They are should one dose of the following ages which is he 2 months, months old, 6 to the 18 months of old, and 4 to 6 years old children. Why polio dose is important of vaccine? – The children’s are united state should inactivated polio vaccine to protect against by the polio or poliomyelitis. They should gets the four doses. One doses at each following ages are the – 2 months. 4 months 6 months 4 through 6 year old

When the children who is travelling to a country where risk of getting polio icon should complete the series are the leaving for the trip. If a children are not to be series before leaving, an accelerated as follows.

1 dose of the age 6 weeks The second dose of 4 more weeks after first dose. The third dose 4 more weeks after second The fourth dose of 6 more months after the third dose.

Over 100 studies are the way to find of vaccine for COVID -19. Vaccination is the one of the world’s most successful health intervention, saving as many as 3 million lives every year. But the further 1.5 million death of year could be avoided with the improved global coverage. Cost of the conflict and vaccine hesitancy are the barriers. Vaccination is the most of successful important development in the human health and saving million of lives a year, according to the world health organization.

In the china where as the outbreak was the first reported are the five vaccine already being in of the human and government say that is in of the ready to end of year. Now the transition is reduce to a reduced serum the medium for human diploid cells without sacrificing cells growth expression, The reduced medium is a combination of two medium which is support to vaccine manufacture under serum free condition with diploid cells such as the growth may be the accomplish with 2% Serum free.

some time to take for cure with the help of vaccine against the diseases – The vaccine is may be month or a year of to the complete, then since a sufficient time of period must be elapse for the subjects to read the vaccine and develop the required antibodies.

BENEFITS – he vaccine is can be freeze dried stored because there no risk killing the pathogen as there is with live attenuated vaccine, they are also safer without any risk of the virus or Bactria mutating back into its the diseases causing forms.

The Dark Pandemic….

The black death or what we call the Bubonic Plague is the most feared epidemic in this whole world till date. The three types of plague are the result of the route of infection: bubonic plague, septicemic plague, and pneumonic plague. Bubonic plague is mainly spread by infected fleas from small animals.It may also result from exposure to the body fluids from a dead plague-infected animal. In the bubonic form of plague, the bacteria enter through the skin through a flea bite and travel via the lymphatic vessels to a lymph node, causing it to swell. Diagnosis is made by finding the bacteria in the blood, sputum, or fluid from lymph nodes.The plague was the cause of the Black Death that swept through Asia, Europe, and Africa in the 14th century and killed an estimated 50 million people.This was about 25% to 60% of the European population. Globally between 2010 and 2015 there were 3248 documented cases, which resulted in 584 deaths. The countries with the greatest number of cases are the Democratic Republic of the Congo, Madagascar, and Peru. For over a decade since 2001, Zambia, India, Malawi, Algeria, China, Peru, and the Democratic Republic of the Congo had the most plague cases with over 1,100 cases in the Democratic Republic of the Congo alone. From 1,000 to 2,000 cases are conservatively reported per year to the WHO. From 2012 to 2017, reflecting political unrest and poor hygienic conditions, Madagascar began to host regular epidemics. Between 1900 and 2015, the United States had 1,036 human plague cases with an average of 9 cases per year. In 2015, 16 people in the Western United States developed plague, including 2 cases in Yosemite National Park. These US cases usually occur in rural northern New Mexico, northern Arizona, southern Colorado, California, southern Oregon, and far western Nevada. In November 2017, the Madagascar Ministry of Health reported an outbreak to WHO (World Health Organization) with more cases and deaths than any recent outbreak in the country. Unusually most of the cases were pneumonic rather than bubonic. In June 2018, a child was confirmed to be the first person in Idaho to be infected by bubonic plague in nearly 30 years. A couple died in May 2019, in Mongolia, while hunting marmots.Another two people in the province of Inner Mongolia, China were treated in November 2019 for the disease. On July 2020, in Bayannur, Inner Mongolia of China it was reported that a case of bubonic plague happened since the last case on May across the border of Inner Mongolia. Then later, the authorities issued a third-level of warning for plague prevention that will last till the end of the year.

First pandemic

The first recorded epidemic affected the Sassanian Empire and their arch-rivals, the Eastern Roman Empire (Byzantine Empire) and was named the Plague of Justinian after emperor Justinian I, who was infected but survived through extensive treatment. The pandemic resulted in the deaths of an estimated 25 million (6th century outbreak) to 50 million people (two centuries of recurrence).The historian Procopius wrote, in Volume II of History of the Wars, of his personal encounter with the plague and the effect it had on the rising empire. In the spring of 542, the plague arrived in Constantinople, working its way from port city to port city and spreading around the Mediterranean Sea, later migrating inland eastward into Asia Minor and west into Greece and Italy. Because the infectious disease spread inland by the transferring of merchandise through Justinian’s efforts in acquiring luxurious goods of the time and exporting supplies, his capital became the leading exporter of the bubonic plague. Procopius, in his work Secret History, declared that Justinian was a demon of an emperor who either created the plague himself or was being punished for his sinfulness.

Second pandemic

In the Late Middle Ages Europe experienced the deadliest disease outbreak in history when the Black Death, the infamous pandemic of bubonic plague, hit in 1347, killing a third of the European human population. Some historians believe that society subsequently became more violent as the mass mortality rate cheapened life and thus increased warfare, crime, popular revolt, waves of flagellants, and persecution. The Black Death originated in Central Asia and spread from Italy and then throughout other European countries. Arab historians Ibn Al-Wardni and Almaqrizi believed the Black Death originated in Mongolia. Chinese records also showed a huge outbreak in Mongolia in the early 1330s.Research published in 2002 suggests that it began in early 1346 in the steppe region, where a plague reservoir stretches from the northwestern shore of the Caspian Sea into southern Russia. The Mongols had cut off the trade route, the Silk Road, between China and Europe which halted the spread of the Black Death from eastern Russia to Western Europe. The epidemic began with an attack that Mongols launched on the Italian merchants’ last trading station in the region, Caffa in the Crimea. In late 1346, plague broke out among the besiegers and from them penetrated into the town. The Mongol forces catapulted plague infected corpses into Caffa as a form of attack one of the first known instances of biological warfare When spring arrived, the Italian merchants fled on their ships, unknowingly carrying the Black Death. Carried by the fleas on rats, the plague initially spread to humans near the Black Sea and then outwards to the rest of Europe as a result of people fleeing from one area to another.

Biological warfare

Some of the earliest instances of biological warfare were said to have been products of the plague, as armies of the 14th century were recorded catapulting diseased corpses over the walls of towns and villages to spread the pestilence. This was done by Jani Beg when he attacked the city of Kaffa in 1343.Later, plague was used during the Second Sino-Japanese War as a bacteriological weapon by the Imperial Japanese Army. These weapons were provided by Shirō Ishii’s units and used in experiments on humans before being used on the field. For example, in 1940, the Imperial Japanese Army Air Service bombed Ningbo with fleas carrying the bubonic plague. During the Khabarovsk War Crime Trials, the accused, such as Major General Kiyoshi Kawashima, testified that, in 1941, 40 members of Unit 731 air-dropped plague-contaminated fleas on Changde. These operations caused epidemic plague outbreaks.